近5年主持的科研項(xiàng)目：

　　1) B[a]P/B[a]PDE致肺癌發(fā)生新機(jī)制---抑制PHLPP2表達(dá)的發(fā)現(xiàn)與分子機(jī)制研究、浙江省自然科學(xué)基金重點(diǎn)項(xiàng)目(LZ14H260001)、30萬(wàn)、2014.01-2017.12.

　　2) DGKα和ζ協(xié)同調(diào)控T 細(xì)胞無(wú)能和調(diào)節(jié)性T 細(xì)胞功能的分子機(jī)制、國(guó)家自然科學(xué)基金面上項(xiàng)目(31270958)、80萬(wàn)、2013.01-2016.12.

　　3) 砷暴露下p50調(diào)控細(xì)胞凋亡的分子機(jī)制研究、國(guó)家自然科學(xué)海外及港澳學(xué)者合作研究基金(81229002)、200萬(wàn)、2013.01-2016.12. (中方負(fù)責(zé)人)

　　4) GM-CSF/TNFa膜表面雙重修飾的前列腺癌治療性疫苗、863計(jì)劃重大項(xiàng)目“疫苗研發(fā)關(guān)鍵技術(shù)與產(chǎn)品研發(fā)”分題(2012AA02A407)、306萬(wàn)、2012.01-2015.12.

　　5) 可溶性腫瘤壞死因子受體II-脂聯(lián)素球部融合蛋白的開(kāi)發(fā)研究、衛(wèi)生部科研基金(201231029)、30萬(wàn)、2012.06-2015.06.

　　6) 連接B[a]P/B[a]PDE誘導(dǎo)的肺慢性炎癥微環(huán)境至肺癌發(fā)生發(fā)展的分子機(jī)制、國(guó)家自然科學(xué)基金重大研究計(jì)劃培育項(xiàng)目(91029706)、60萬(wàn)、2011.01-2013.12.

　　7) JNK1經(jīng)VHL-非依賴途徑調(diào)節(jié)HIF-1α蛋白降解的新功能及其機(jī)制研究、國(guó)家自然科學(xué)基金面上項(xiàng)目(30971516)、30萬(wàn)、2010.01-2012.12.

　　8) IKK/NFκBp50/GADD45α凋亡通路的分子基礎(chǔ)、國(guó)家自然科學(xué)基金海外及港澳學(xué)者合作基金(30928023)、20萬(wàn)、2010.01-2011.12. (中方負(fù)責(zé)人)

　　9) 可溶性腫瘤壞死因子受體II-脂聯(lián)素球部融合蛋白的開(kāi)發(fā)研究、國(guó)家“重大新藥創(chuàng)制”科技重大專項(xiàng)項(xiàng)目(2009ZX09103-649)、150萬(wàn)、2009.01-2010.12.

　　10) GM-CSF/TNFα膜表面雙重修飾的前列腺癌治療性疫苗的研制、浙江省重大科技專項(xiàng)(2008C14082)、100萬(wàn)、2009.01-2011.12.

　　11) 浙江省自然科學(xué)基金杰出青年團(tuán)隊(duì)(R2080407)、51萬(wàn)、2009.01-2011.12.

　　12) 浙江省衛(wèi)生高層次創(chuàng)新人才培養(yǎng)工程、80萬(wàn)、2008.07-2013.06.

　　13) 蛋白質(zhì)錨定技術(shù)平臺(tái)的開(kāi)發(fā)研究(2008R10031)、浙江省錢(qián)江人才計(jì)劃、10萬(wàn)、2008.01-2010.12.

　　14) 蛋白質(zhì)錨定技術(shù)用于表淺膀胱癌術(shù)后復(fù)發(fā)的防治， 863計(jì)劃課題(2006AA02Z4C4)、260 萬(wàn)元、2006.12-2008.12.

　　發(fā)表的代表性論文：(*通訊作者)

　　1. Zhang D, Liang Y, Xie Q, Gao G, Wei J, Huang H, Li J, Gao J, Huang C*. A novel post-translational modification of nucleolin, SUMOylation at K294, mediates arsenite-induced cell death by regulating gadd45a mRNA stability. J Biol Chem. 2015 Jan 5. [Epub ahead of print]

　　2. Lin M, Wang J, Zhou G, Wang J, Wu N, Lu J, Gao J, Chen X, Shi J, Zuo X*, Fan C*.Programmable engineering of a biosensing interface with tetrahedral DNA nanostructures for ultrasensitive DNA detection. Angew Chem Int Ed Engl. 2014 Dec 29. [Epub ahead of print]

　　3. Jin H, Yu Y, Hu Y, Lu C, Li J, Gu J, Zhang L, Huang H, Zhang D, Wu X, Gao J*, Huang C*. Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines. Oncotarget. 2014 Nov. 5 [Epub ahead of print]。

　　4. Wang J, Lu J, Su S, Gao J*, Huang Q, Wang L, Huang W, Zuo X*. Binding-induced collapse of DNA nano-assembly for naked-eye detection of ATP with plasmonic gold nanoparticles. Biosens Bioelectron. 2014 Oct. 18 [Epub ahead of print]. (影響因子6.451)

　　5. Xiang D, Zhang H, Bai J, Ma J, Li M, Gao J, Wang C. Clinical application of neutrophil gelatinase-associated lipocalin in the revised chronic kidney disease classification. Int J Clin Exp Pathol. 2014;7(10)：7172-81.

　　6. Cai Q, Zhao A, Yin Y, Ma L, Jiao Z, Zhi H, Lai S, Cheng S, Yang H, Lu Y*, Siminovitch K*, Gao J*. Efficient production of sTNFRII-gAD fusion protein in large quantity by use of the modified CHO-S cell expression system. PloS One 2014;9(10)：e111229. (影響因子3.534)

　　7. Wu W, Li J, Pan D, Li J, Song S, Rong M, Li Z, Gao J, Lu J. Gold nanoparticle-based enzyme-linked antibody-aptamer sandwich assay for detection of Salmonella Typhimurium. ACS Appl Mater Interfaces. 2014; 6(19)：16974-81.

　　8. Lan J, Yang K, Byrd D, Hu N, Amet T, Shepherd N, Desai M, Gao J, Gupta S, Sun Y, Yu Q. Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol. 2014; 192(6)：2643-50.

　　9. Wei J, Du K, Cai Q, Ma L, Jiao Z, Tan J, Xu Z, Li J, Luo W, Chen J, Gao J*, Zhang D*, Huang C*. Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NFκB-independent manner. Toxicology. 2014;325:67-73.

　　10. Chen X, Zhou G, Song P, Wang J, Gao J, Lu J, Fan C, Zuo X. Ultrasensitive electrochemical detection of prostate-specific antigen by using antibodies anchored on a DNA nanostructural scaffold. Anal Chem. 2014;86(15)：7337-42.

　　11. Wang Y, Zhao W, Zhang L, Zhao YN, Li F, Zhang Z, Dai YD, Li WF, Qiao Y, Chen C, Gao J*, Zhu M*. Molecular and cellular basis of the regulation of lymphatic contractility and lymphatic absorption. Int J Biochem Cell Biol. 2014; 53:134-40.(影響因子4.24)

　　12. Qiao Y, He W, Chen C, Zhang C, Zhao W, Wang P, Zhang L, Wu Y, Yang X, Peng Y, Gao J, Kamm K, Stull J, Zhu M. Myosin Phosphatase Target Subunit 1 (MYPT1) Regulates the Contraction and Relaxation of Vascular Smooth Muscle and Maintains Blood Pressure. J Biol Chem. 2014;289(32)：22512-23.

　　13. Wu J, Shin J, Xie D, Wang H, Gao J, Zhong XP. Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. J Immunol. 2014;192(6)：2643-50.

　　14. Shin J, Wang S, Deng W, Wu J, Gao J*, Zhong XP*. Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc Natl Acad Sci USA. 2014; 111(8)：E776-83. (影響因子9.737)

　　15. Yu Y, Zhang D, Huang H, Li J, Zhang M, Wan Y, Gao J, Huang C. NF-kB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1.Oncogene 2014; 33:996-1005.

　　16. Sun Q, Teong B, Chen IF, Chang SJ, Gao J, Kuo SM. Enhanced apoptotic effects of dihydroartemisinin-aggregated gelatin and hyaluronan nanoparticles on human lung cancer cells. J Biomed Mater Res B Appl Biomater. 2014; 102(3)：455-62.

　　17. Huang H, Ma L, Li J, Yu Y, Zhang D, Wei J, Jin H, Xu D, Gao J*, Huang C*. NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. Oncotarget 2014; 5:493-505. (影響因子6.636)

　　18. Wan Y, Wang P, Su Y, Zhu X, Yang S, Lu J, Gao J, Fan C, Huang Q. Ultrasensitive electrochemical DNA sensor based on the target induced structural switching and surface-initiated enzymatic polymerization. Biosens Bioelectron. 2014;55:231-6.

　　19. Deng X, Yang H, He X, Liao Y, Zheng C, Zhou Q, Zhu C, Zhang G, Gao J, Zhou N. Activation of Bombyx neuropeptide G protein-coupled receptor A4 via a Gαi-dependent signaling pathway by direct interaction with neuropeptide F from silkworm, Bombyx mori. Insect Biochem Mol Biol. 2014;45:77-88.

　　20. Wu J, Zhang XJ, Shi KQ, Chen YP, Ren YF, Song YJ, Li G, Xue YF, Fang YX, Deng ZJ, Xu X, Gao J, Tang KF. Hepatitis B surface antigen (HBsAg) inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells. Carcinogenesis. 2014; 35(1)：155-63.(影響因子5.635)

　　21. Chang C, Zhao W, Xie B, Deng Y, Han T, Cui Y, Dai Y, Zhang Z, Gao J*, Guo H*, Yan J*. Pao Pereira extract suppresses castration-resistant prostate cancer cell growth, survival, and invasion through inhibition of NFκB signaling. Integr Cancer Ther 2013; 13(3)：249-258.(影響因子2.354)

　　22. Tong Y, Li F, Lu Y, Cao Y, Gao J*, Liu J*. Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary. Mol Reprod Dev 2013;80(12)：1018-34. (影響因子2.812)

　　23. Qin K, Ding T, Xiao Y, Ma W, Wang Z, Gao J, Zhao L. Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. PLoS One 2013;8(12)：e82130.

　　24. Li X, Xu X, Jin A, Jia Q, Zhou H, Kang S, Lou Y, Gao J*, Lu J*. Self-assembled HCV core virus-like particles targeted and inhibited tumor cell migration and invasion. Nanoscale Res Lett 2013 Sep 27;8(1)：401. (影響因子2.542)

　　25. Du K, Yu Y, Zhang D, Luo W, Huang H, Chen J, Gao J, Huang C. NFκB1 (p50) suppresses SOD2 expression via inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis. Mol Biol Cell. 2013;24(22)：3577-83. (影響因子4.604)

　　26. Xiang D, Zhang H, Bai J, Ma J, Li M, Gao W, Zhang X, Gao J*, Wang C*. Particle-enhanced turbidimetric immunoassay for determination of serum neutrophil gelatinase-associated lipocalin on the Roche Cobas c501 analyzer. Clin Biochem. 2013;46(16-17)：1756-60 2013. (影響因子2.45)

　　27. Yu Y, Huang H, Li J, Zhang J, Gao J, Lu B, Huang C. GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment. Cell Death Dis. 2013;4:e637. (影響因子6.044)

　　28. Bianying F, Linjie G, Lihua W, Fan L, Jianxin L, J Gao, Chunhai F, Qing H. A graphene oxide-based fluorescent biosensor for the analysis of Peptide-receptor interactions and imaging in somatostatin receptor subtype 2 overexpressed tumor cells. Anal Chem. 2013;85(16)：7732-7.

　　29. Y Li, L Du*, H Qiu, G Zhao, L Wang, Y Zhou, S Jiang, J Gao*. A recombinant protein containing highly conserved hemagglutinin residues 81–122 of influenza H5N1 induces strong humoral and mucosal immune responses. BioScience Trends.2013;7(3)：129-37. (影響因子1.582)

　　30. Zhao YN, Li WF, Li F, Zhang Z, Dai YD, Xu AL, Qi C, Gao J*, Gao J*. Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway. Biochem Biophys Res Commun. 2013; 435(4)：597-602. (影響因子2.406)

　　31. Zhu JJ, Xu YQ, He JH, Yu HP, Huang CJ, Gao J, Dong QX, Xuan YX, Li CQ. Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. J Appl Toxicol. 2013; 67(1)：25-32. (影響因子2.150)

　　32. He JH, Guo SY, Zhu F, Zhu JJ, Chen YX, Huang CJ, Gao J, Dong QX, Xuan YX, Li CQ. A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity. J Pharmacol Toxicol Methods 2013; 67(1)：25-32.

　　33. Shi X, Zhang X, Li J, Guo F, Hu Z, Jing Y, Bai L, Chen S, Wan P, Wang F, Gao J, Tan W. Sequential administration of GM-CSF and IL-2 surface-modified MB49 cells vaccines against the metastatic bladder cancer. Urol Oncol 2013;31(6)：883-93. (影響因子3.216)

　　34. Cao Z, Zhang R, Li J, Huang H, Zhang D, Zhang J, Gao J*, Chen J*, Huang C*. X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis. J Biol Chem. 2013; 288(28)：20238-47.(影響因子4.651)

　　35. Che X, Liu J, Huang H, Mi X, Xia Q, Li J, Zhang D, Ke Q*, Gao J*, Huang C*. p27 Suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure. Biochim Biophys Acta - Mol Cell Res. 2013; 1832(9)： 2083-91. (影響因子4.808)

　　36. Yu Y, Li J, Wan Y, Lu J, Gao J*, Huang C*. GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression. PLoS One 2013; 8(3)：e57185. (影響因子4.092)

　　37. Fan Li, Hao Pei, Lihua Wang*, Jianxin Lu, Jimin Gao*, Bowei Jiang, Xingchun Zhao, Chunhai Fan*. Nanomaterial-based fluorescent DNA analysis: A comparative study of the quenching effects of graphene oxide, carbon nanotubes, and gold nanoparticles. Adv. Funct. Mater. 2013; 23(33)：4140–4148.(影響因子9.765)

　　38. Mao X, Wei M, Zhu C, Lu J, Gao J*, Simon A, Chen N, Shi J, Huang Q, Fan C*. Real time in vitro regulation of DNA methylation using a 5-fluorouracil conjugated DNA-based stimuli-responsive platform. ACS Appl Mater Interfaces. 2013; 5(7)：2604-9.(影響因子5.008)

　　39. Shi H, Zhang Y, Zhang G, Guo J, Zhang X, Song H, Lv J, Gao J*, Wang Y, Chen L*, Wang Y*. Systematic functional comparative analysis of four single-stranded DNA-binding proteins and their affection on viral RNA metabolism. PLoS One 2013; 8(1)： e55076. (影響因子4.092)

　　40. Cao Q, Zhang X, Lu L, Yang L, Gao J, Gao Y, Ma H, Cao Y. Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. Development. 2012;139(21)：3950-61.

　　41. Du L, Li Y, Gao J, Zhou Y, Jiang S. Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses. Rev Med Virol. 2012;22(6)：412-9.

　　42. Su S, Wu W, Gao J*, Lu J, Fan C*. Nanomaterials-based sensors for applications in environmental monitoring. J Mater Chem 2012; 22:18101-18110. (影響因子6.101)

　　43. Pei H, Li J, Lv M, Wang J, Gao J, Lu J, Li Y, Huang Q, Hu J, Fan C. A graphene-based sensor array for high-precision and adaptive target identification with ensemble aptamers. J Am Chem Soc. 2012; 134(33)：13843-9. (影響因子10.677)

　　44. Krishna S, Xie D, Gorentla B, Shin J, Gao J, Zhong XP. Chronic activation of the kinase IKKβ impairs T cell function and survival. J Immunol 2012 ;189(3)：1209-19. (影響因子5.745)

　　45. Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, Zhu L, Gao J, Huang C. The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1α mRNA Stability. J Biol Chem. 2012; 287(41)：34361-71. (影響因子5.328)

　　46. Luo M, Liu D, Zhang L, Huang S, Yang W, Zhang L, Cui T, Ma H, Wang Z, Sun Q, Xiong C, Zhu J, Li J, Wu X, Jin L, Hu Z, Gao J*. Protective effects of a novel trimerized sTNFRII on acute liver injury. Int Immunopharmacol. 2012;13:88-92. (影響因子2.325)

　　47. Bai L, Hu Z, Wang F, Xu X, Xia C, Jin L, Li J, Gao J*. Generation of streptavidin-tagged human-granulocyte macrophage colony-stimulating factor fusion proteins.Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1389-93.

　　48. Zhang X, Shi X, Li J, Hu Z, Zhou D, Gao J*, Tan W*. A Novel Therapeutic Vaccine of Mouse GM-CSF Surface Modified MB49 Cells Against Metastatic Bladder Cancer. J Urol 2012; 87:1071-9.(影響因子3.746)

　　49. Chen Y, Shen S, Gorentla BK, Gao J*, Zhong XP*. Murine regulatory T cells contain hyperproliferative and death-Prone subsets with differential ICOS expression. J Immunol 2012; 188:1698-707. (影響因子5.745)

　　50. Shi Y, Huang H, Deng X, He X, Yang J, Yang H, Shi L, Mei L, Gao J*, Zhou N*. Identification and Functional Characterization of Two Orphan G-protein-coupled Receptors for Adipokinetic Hormones from Silkworm Bombyx mori. J Biol Chem 2011; 286(49)：42390-402. (影響因子5.328)

　　51. Zhang X, Shi X, Li J, Hu Z, Guo F, Huang X, Zhang Z, Sun P, Jing Y, Gao J, Tan W. Novel immunotherapy for metastatic bladder cancer using vaccine of human interleukin-2 surface-modified MB 49 cells. Urology 2011;78:722.e1-6. (影響因子2.334)

　　52. Liu G, Chen H, Peng H, Song S, Gao J, Lu J, Ding M, Li L, Ren S, Zou Z, Fan C. A carbon nanotube-based high-sensitivity electrochemical immunosensor for rapid and portable detection of clenbuterol. Biosens Bioelectron 2011; 28:308-13. (影響因子5.437)

　　53. Huang H, Deng X, He X, Yang W, Li G, Shi Y, Shi L, Mei L, Gao J, Zhou N*. Identification of distinct c-terminal domains of the Bombyx adipokinetic hormone receptor that are essential for receptor export, phosphorylation and internalization. Cell Signal 2011; 23:1455-65.

　　54. He Q, Li J, Yin W, Song Z, Zhang Z, Yi T, Tang J, Wu D, Lu Y, Wang Z, Liu D, Zhang X, Hu Z, Gao J*. Low-dose paclitaxel enhances the anti-tumor efficacy of GM-CSF-surface-modified whole-tumor-cell vaccine in mouse model of prostate cancer. Cancer Immunol Immunother 2011;60:715-30.(影響因子3.701)

　　55. Zhang Z, Xu X, Zhang X, Chen X, Chen Q, Dong L, Hu Z, Li J, Gao J*.The therapeutic potential of SA-sCD40L in the orthotopic model of superficial bladder cancer. Acta Oncologica 2011;50:1111-8.(影響因子3.330)

　　56. Chen Y, Nie X, Cui X, Wu W, Zhang J, Wen C, Gao J*, Jinxin Lu*. Direct Colorimetric Biosensors from Polydiacetylenes. Curr Org Chem 2011;15: 518-533.(影響因子2.920)

　　57. Zhang F, Wu J, Xu C, Lin X, Zhao H, Lu J, Zhang Y, Lu J, Zhang X, Ma J, Shu Y, Lou Y, Gao J*, Wang Y*. Infectivity of pseudotyped particles pairing hemagglutinin of highly pathogenic avian influenza a H5N1 virus with neuraminidases of the 2009 pandemic H1N1 and a seasonal H3N2. J Bioterr Biodef 2011; 2:1-6.

　　58. Wen B, Deng Y, Guan J, Yan W, Wang Y, Tan W, Gao J*. Signal peptide replacements enhance expression and secretion of hepatitis C virus envelope glycoproteins. Acta Biochim Biophys Sin (Shanghai). 2011 ;43:96-102.(影響因子1.547)

　　59. Wu W, Hu H, Li F, Wang L, Gao J, Lu J, Fan C. A graphene oxide-based nano-beacon for DNA phosphorylation analysis. Chem Commun (Camb).2010;47:1201-3.(影響因子5.504)

　　60. Wu J, Zhang F, Wang M, Xu C, Song J, Zhou J, Lin X, Zhang Y, Wu X, Tan W, Lu J, Zhao H, Gao J, Zhao P, Lu J, Wang Y. Characterization of Neuraminidases from the Highly Pathogenic Avian H5N1 and 2009 Pandemic H1N1 Influenza A Viruses. PLoS One 2010; 5:e15825.

　　61. Wei B, Gao J, Huang XP, Ji G, Jin JP. Mutual rescues between two dominant-negative mutations in cardiac troponin I and cardiac troponin T. J Biol Chem. 2010; 285:27806-16. (影響因子5.328)

　　62. Zhou Y, Huang Q, Gao J, Lu J, Shen X, Fan C. A dumbbell probe-mediated rolling circle amplification strategy for highly sensitive microRNA detection. Nucleic Acids Res. 2010; 38(15)：e156.(影響因子7.479)

　　63. Huang X, Yu HS, Chen Z, Li JL, Hu ZM, Gao J*. A novel immunotherapy for superficial bladder cancer by the immobilization of streptavidintagged bioactive IL2 on the biotinylated mucosal surface of the bladder wall. Chin J Cancer 2010; 29:611-6.

　　64. Yin W, He Q, Hu Z, Chen Z, Qifeng M, Zhichun S, Zhihui Q, Xiaoxia N, Li J, Gao J*. A novel therapeutic vaccine of GM-CSF/TNFα surface-modified RM-1 cells against the orthotopic prostate cancer. Vaccine 2010; 28: 4946-4953. (影響因子3.766)

　　65. Zhang D, Li J, Costa M, Gao J*, Huang C*. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 2010; 70:813-23. (影響因子8.234)

　　66. Hu Z, Tan W, Zhang L, Liang Z, Xu C, Su H, Lu J, Gao J*. A novel immunotherapy for superficial bladder cancer by intravesical immobilization of GM-CSF. J Cell Mol Med. 2010; 14:1836-44. (影響因子4.753)

　　67. Zhang D, Li J, Gao J*, Huang C*. c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol Appl Pharmacol. 2009; 235(1)：18-24. (影響因子4.447)

　　68. Zhang D, Li J, Song L, Ouyang W, Gao J*, Huang C*. A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression. Mol Cancer Res. 2008; 6(1)：165-74. (影響因子4.288)

　　69. Ouyang W, Luo W, Zhang D, Jian J, Ma Q, Li J, Shi X, Chen J, Gao J, Huang C. PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ Health Perspect. 2008;116(1)：1-6. (影響因子5.8)

　　70. Gao J*, Huang S, Li M, Luo R, Wang X, Takashima A. GM-CSF- modified mouse B16.F10 melanoma whole cell vaccine. Vaccine 2006; 24: 5265-5268.(影響因子3.007)

　　71. Mizumoto N, Gao J, Matsushima H, Ogawa1 Y, Takashima A. Discovery of novel immunostimulants by dendritic cell-based functional screening. Blood 2005; 106:3082-3089.(影響因子10.12)

　　72. Z. Urban, J. Gao, FM. Pope, EC. Davis. Autosomal Dominant Cutis Laxa with severe lung disease: Synthesis and Matrix Deposition of Mutant Tropoelastin. J Invest Dermatol. 2005; 124: 1193-1199. (影響因子4.194)

　　73. Gao J, Takashima A. Cloning & Characterization of Actin, Tr 2 and Tr 4 genes of Trichophyton rubrum. J Clin Microbiol. 2004; 42: 3298-3299. (影響因子3.489)

　　74. Patterson CE, Gao J, Rooney AP, Davis EC. Genomic organization of mouse and human 65 kDa FK506-binding protein (FKBP65) genes and evolution of the FKBP multigene family. Geneomics 2002; 79: 881-889. (影響因子3.488)

　　75. Gao J, Waber L, Bennett MJ, Gibson KM, Cohen JC. Cloning and mutational analysis of human malonyl coenzyme A decarboxylase. J. Lipid Research 1999; 40:178-182. (影響因子3.893)

　　76. Vega GL, Gao J, Bersot TP, Mahley RW, Verstraaete R, Grundy SM, White A, Cohen JC. The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen- mediated stimulation of hepatic lipase activity. J. Lipid Research1998, 39: 1520-1524. (影響因子3.893)

　　77. Li S, Gao J, Satoh T, Friedman T, Edling A, Koch U, Choksi S, Han X, Korngold R, Huang Z. A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics. Proc Natl Acad Sci USA 1997; 94: 73-78. (影響因子9.737)

　　78. Gao J, Hwang J, Jin JP. Complete nucleotide sequence and structural organization of mouse h1-calponin gene. Biochem Biophys Res Commun1996; 218: 292-297. (影響因子2.406)

　　專利：

　　1. 高基民。鏈親和素/粒細(xì)胞-巨噬細(xì)胞集落刺激因子融合蛋白。發(fā)明專利號(hào)ZL200410052536.4

　　2. 高基民�？扇苄阅[瘤壞死因子受體II-“脂聯(lián)素”球部融合蛋白。發(fā)明專利號(hào)ZL200510100468.9

　　3. 高基民，胡志明，周明乾，林來(lái)新妹。鏈親和素-白細(xì)胞介素2融合蛋白。發(fā)明專利申請(qǐng)?zhí)?00710030119.3

　　4. 高基民，林來(lái)新妹，周明乾，胡志明。鏈親和素-腫瘤壞死因子a融合蛋白。發(fā)明專利申請(qǐng)?zhí)?00710030120.6

　　5. 高基民，林來(lái)新妹，蘇華，張琳。綠色熒光蛋白/鏈親和素融合蛋白。發(fā)明專利申請(qǐng)?zhí)?009100030119.3

　　6. 高基民，胡志明，林來(lái)新妹，蘇華，張琳。鏈親和素-白細(xì)胞介素15融合蛋白。發(fā)明專利申請(qǐng)?zhí)?00910004309.3

　　7. 高基民，張政，許曉玲。鏈親和素/白細(xì)胞介素7融合蛋白。發(fā)明專利申請(qǐng)?zhí)?01010003372.1

　　8. 高基民，法萍萍，許曉玲。鏈親和素/白細(xì)胞介素21融合蛋白。發(fā)明專利申請(qǐng)?zhí)?01010003373.6

　　9. 高基民，尹衛(wèi)華、許曉玲。GM-CSF/TNFα膜表面修飾的前列腺癌治療性疫苗。發(fā)明專利號(hào)ZL201010195260.0

　　10. 高基民，鄒立林，許曉玲。人心肌肌鈣蛋白T/人心肌肌鈣蛋白I融合蛋白。發(fā)明專利申請(qǐng)?zhí)?01010228835.4

　　11. 高基民、張振、李金龍、許曉玲。鏈親和素/sCD40L融合蛋白。發(fā)明專利申請(qǐng)?zhí)?01010228717.3

　　12. 高基民，唐佳，許曉玲。一種新型的人白細(xì)胞介素-11。發(fā)明專利申請(qǐng)?zhí)?01110026277.8

　　13. 高基民，呂建新、鄒立林、郭芳芳、許曉玲。用于結(jié)核桿菌培養(yǎng)濾液蛋白10定量檢測(cè)的標(biāo)準(zhǔn)品研制。發(fā)明專利號(hào)ZL201110060104.8

　　14. 高基民、董小巖、劉丹、陸月、吳小兵。腫瘤壞死因子受體Ⅱ-脂聯(lián)素球部融合蛋白改構(gòu)體快速篩選方法及應(yīng)用。發(fā)明專利號(hào)ZL201110073658.1

　　專著：

　　1. 《臨床分子生物學(xué)檢驗(yàn)》(第3版)，2012，人民衛(wèi)生出版社(ISNB 978-7-117-15269-3)(副主編)

　　2. 《分子診斷學(xué)實(shí)驗(yàn)指導(dǎo)》，2010，中國(guó)醫(yī)藥科技出版社(ISNB 978-7-5067-4534-5)(主編)

　　3. 《分子診斷學(xué)》，2010，中國(guó)醫(yī)藥科技出版社(ISNB 978-7-5-67-4537-6)(副主編)

　　4. 《分子生物學(xué)》，2010，高等教育出版社(ISNB 978-7-04-030529-6)(副主編)

　　科技獎(jiǎng)勵(lì)：

　　1. 細(xì)胞膜表面錨定修飾技術(shù)與新型腫瘤細(xì)胞疫苗。2013年浙江省科學(xué)技術(shù)獎(jiǎng)“一等獎(jiǎng)”(排名1/10)

　　2. 高基民杰出青年團(tuán)隊(duì)。浙江省自然科學(xué)基金“十一五”優(yōu)秀項(xiàng)目。(排名1/10)

　　3. “新型腫瘤細(xì)胞生物治療項(xiàng)目”創(chuàng)業(yè)計(jì)劃書(shū)。2008年全國(guó)大學(xué)生“創(chuàng)業(yè)杯”銅獎(jiǎng) (指導(dǎo)老師)

　　4. 白介素II/LAK細(xì)胞制備和應(yīng)用技術(shù)的綜合研究。1994年廣東省科技進(jìn)步獎(jiǎng)“二等獎(jiǎng)”。(排名3/6)

　　5. 人乳頭瘤病毒6，11，16 和18 型DNA檢測(cè)、早期基因克隆及表達(dá)研究。1991年軍隊(duì)科技進(jìn)步獎(jiǎng)“二等獎(jiǎng)”。(排名3/5)

　　附錄3：高基民教授研究團(tuán)隊(duì)簡(jiǎn)況

　　本實(shí)驗(yàn)室(http://www.zjmolab.com/)研究方向：炎癥相關(guān)疾病(腫瘤、自身免疫性疾病等)發(fā)生發(fā)展機(jī)制及其預(yù)防、診治研究，如環(huán)境致癌物(如砷、鎳、苯并芘等)的致癌機(jī)制，T淋巴細(xì)胞等免疫細(xì)胞的發(fā)育調(diào)控及其在腫瘤、器官移植和自身免疫性疾病中的作用，細(xì)胞膜表面錨定修飾的腫瘤細(xì)胞疫苗以及新型腫瘤壞死因子拮抗劑的研制、干細(xì)胞的轉(zhuǎn)化醫(yī)學(xué)研究等。

　　本實(shí)驗(yàn)室擁有強(qiáng)大的師資研究團(tuán)隊(duì)，部分導(dǎo)師簡(jiǎn)介：

　　黃傳書(shū)教授(國(guó)家“千人”)

　　http://www.med.nyu.edu/biosketch/huangc05/publications

　　Dr. Katherine Siminovitich(加拿大皇家科學(xué)院院士、浙江省“千人”)

　　http://www.mshri.on.ca/simino/pages/kathy.htm

　　Dr. Andras Nagy (加拿大皇家科學(xué)院院士)

　　Dr. Andras Nagy — The Lunenfeld-Tanenbaum Research Institute

　　鐘小平教授(浙江省“千人”)

　　http://cmb.duke.edu/research/faculty/xiaoping-zhong

　　喻啟桂教授(浙江省“千人”)

　　http://micro.medicine.iu.edu/faculty/primary-faculty/andy-qigui-yu-m-d-ph-d/

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